Chapter 60: Drug discovery and development

Chapter 60: Drug discovery and development

Complete Chapter Questions With Answers

Sample Questions Are Posted Below

MULTIPLE CHOICE

1. Since 1980, the drug development process has been characterized by

1. rising sales and development costs
2. rising sales and declining development costs
3. declining sales and rising development costs
4. declining sales and development costs
5. increasing registration of new compounds

Answer a: rising sales and development costs

1. Phase II clinical trials are primarily concerned with determining

1. drug safety in a small group of normal subjects
2. drug efficacy and dosage in a small group of diseased patients
3. drug pharmacokinetics in a large group of diseased patients
4. statistical evidence of drug efficacy in thousands of subjects
5. long-term adverse effects after a drug has been marketed

Answer b: drug efficacy and dosage in a small group of diseased patients

1. The main disadvantage of natural products as lead compounds for drug development is their

1. rarity
2. complexity
3. toxicity
4. inactivity
5. insolubility

Answer b: complexity