Chapter 03: Inflammation and Repair

Chapter 03: Inflammation and Repair

Complete Chapter Questions With Answers

Sample Questions Are Posted Below

MULTIPLE CHOICE

1. Transmembrane adhesive heterodimeric proteins, composed of an a and a ß chain, are expressed on activated leukocytes during inflammation. They bind primarily to intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), both of which belong to the family of proteins known as
2. selectins
3. integrins
4. immunoglobulins
5. lectins
6. growth factors

ANS: C, Surface proteins expressed on activated leukocytes are integrins, and they bind to intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), which belong to the immunoglobulin family of proteins.

2. Which of the following mediators of inflammation has chemotactic properties and is increased in persons taking aspirin?
3. Thromboxane A₂
4. Prostaglandin E₂
5. Platelet-activating factor
6. Leukotriene B₄
7. Interleukin-1

ANS: D, Leukotriene B₄ is chemotactic. It is increased in persons who take aspirin, because aspirin inhibits the cyclooxygenase pathway, thus shunting more arachidonic acid early derivatives into the lipoxygenase pathway. This promotes the synthesis of leukotrienes.

3. A 2-year-old child known to suffer from recurrent bacterial infections and poor wound healing was found to have leukocyte adhesion molecule deficiency 1 (LAD-1). The leukocytes of this patient do not express CD18, a molecule classified as belonging to the family of
4. selectins
5. integrins
6. lectin type of vascular adhesion molecules
7. aminotransferases
8. glycosidases

ANS: B, LAD-1 is characterized by a deficiency of CD18, a cell surface molecule that is a ß₂ integrin. The infections occur because the defective leukocytes cannot adhere to endothelial cells, cannot spread and attach, and cannot phagocytose bacteria. PBD7 62

4. Bradykinin is produced from a high-molecular weight kininogen circulating in the blood. This reaction is mediated by
5. coagulation factor X
6. kallikrein
7. Hageman factor
8. complement C3
9. protein C

ANS: B, Kallikrein promotes the formation of bradykinin from the high-molecular weight kininogen. PBD7 67