Pharmacotherapeutics for Advanced Practice 3rd Edition by Virginia Poole Arcangelo, Andrew M. Peterson
Pharmacotherapeutics for Advanced Practice 3rd Edition by Virginia Poole Arcangelo, Andrew M. Peterson
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Chapter 10. Pharmacogenomics
Complete Chapter Questions With Answers
Sample Questions Are Posted Below
MULTIPLE CHOICE
| A. | Poor metabolizers (PMs) who lack a working enzyme |
| B. | Intermediate metabolizers (IMs) who have one working, wild-type allele and one mutant allele |
| C. | Extensive metabolizers (EMs), with two normally functioning alleles |
| D. | All of the above |
ANS: D PTS: 1
| A. | A need to monitor drugs metabolized by 2D6 for toxicity |
| B. | Increased dosages needed of drugs metabolized by 2D6, such as the SSRIs |
| C. | Decreased conversion of codeine to morphine by CYP 2D6 |
| D. | The need for lowered dosages of drugs, such as beta blockers |
ANS: B PTS: 1
| A. | Lead to toxic levels of rifampin and must be monitored closely |
| B. | Cause toxic levels of drugs, such as oral contraceptives, when co-administered |
| C. | Induce the metabolism of drugs, such as oral contraceptives, leading to therapeutic failure |
| D. | Cause nonspecific changes in drug metabolism |
ANS: C PTS: 1
| A. | Decreased therapeutic levels of quinidine |
| B. | Increased therapeutic levels of quinidine |
| C. | Decreased levels of a co-administered drug, such as digoxin, that requires P-glycoprotein for absorption and elimination |
| D. | Increased levels of a co-administered drug, such as digoxin, that requires P-glycoprotein for absorption and elimination |
ANS: D PTS: 1
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