Pharmacology for Canadian health Care Practice 3rd Edition By Linda Lane Lilley PhD RN - Test Bank

Pharmacology for Canadian health Care Practice 3rd Edition By Linda Lane Lilley PhD RN – Test Bank

 

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Sample Questions Are Posted Below

 

Chapter 05: Gene Therapy and Pharmacogenomics

Lilley: Pharmacology for Canadian Health Care Practice, 3rd Canadian Edition

 

MULTIPLE CHOICE

 

1. Which is the most important compound that transfers genes from parents to offspring?

a.	Chromatin
b.	Deoxyribonucleic acid (DNA)
c.	Alleles
d.	Ribonucleic acid

 

 

ANS:  B

It is now recognized that DNA is the most important body compound that serves to transfer genes from parents to offspring.

 

DIF:    Cognitive Level: Knowledge            REF:   pp. 82-83

 

2. Which is manufactured as a result of indirect gene therapy?

a.	Vitamin K
b.	epoetin (Eprex)
c.	Human insulin
d.	Heparin

 

 

ANS:  C

A recombinant form of human insulin is one of the most widespread uses of indirect gene therapy.

 

DIF:    Cognitive Level: Comprehension     REF:   p. 85

 

3. Eugenics is defined as

a.	the use of gene therapy to prevent disease.
b.	the development of new drugs based on gene therapy.
c.	the intentional selection, before birth, of genotypes that are considered more desirable than others.
d.	the determination of genetic factors that influence a person’s response to medications.

 

 

ANS:  C

Eugenics is the intentional selection, before birth, of genotypes that are considered more desirable than others. Eugenics is a major ethical issue related to gene therapy.

 

DIF:    Cognitive Level: Knowledge            REF:   p. 85

 

4. What is the main purpose of the Human Genome Project?

a.	To study genetic diseases
b.	To study genetic traits in humans
c.	To discover new genetic diseases
d.	To describe the entire genome of a human being

 

 

ANS:  D

The Human Genome Project was undertaken to describe in detail the entire genome of a human being.

 

DIF:    Cognitive Level: Knowledge            REF:   p. 84

 

5. Genotyping for the presence of cytochrome P-450 2D6 (CYP2D6) enzymes and alleles will be helpful in which area of medicine?

a.	Cardiology
b.	Psychiatry
c.	Respirology
d.	Oncology

 

 

ANS:  B

Psychiatry and general medicine will benefit. Genotyping for the presence of CYP2D6 will determine whether patients are poor, intermediate, extensive, or ultrarapid metabolizers with these enzymes, which will help guide the prescribing of specific medications.

 

DIF:    Cognitive Level: Comprehension     REF:   p. 87

 

SHORT ANSWER

 

1. Name one clinical application of pharmacogenomics.

 

ANS:

Several possible clinical applications are listed in Table 5-1: Clinical Applications of Pharmacogenomics.

 

DIF:    Cognitive Level: Application           REF:   p. 87