Chapter 06: Immunity

Chapter 06: Immunity

Complete Chapter Questions With Answers

Sample Questions Are Posted Below

MULTIPLE CHOICE

1. Which of the following is the most abundant bronchospasm-inducing arachidonic acid derivative generated by cyclooxygenase in the mast cells?
2. Leukotriene B₄
3. Prostacyclin
4. Prostaglandin D₂
5. Thromboxane
6. Lipoxin

ANS: C, Prostaglandin D₂ is the most abundant arachidonic acid derivative produced through the cyclooxygenase pathway. It causes bronchospasm and increased mucus production.

2. A 40-year-old man presents with hemoptysis and renal failure. A kidney biopsy specimen revealed linear deposits of IgG in glomerular basement membranes and crescents between the glomerular capillary loops and the Bowman capsule.  The antibodies causing these pathologic changes react with
3. laminin
4. fibronectin
5. collagen type I
6. collagen type IV
7. podocytes of glomerular epithelial cells

ANS: D, This man has Goodpasture syndrome, in which the body produces autoantibodies to the globular part of type IV collagen in the glomerular basement membranes and the lungs.

3. Which antibody can most effectively activate complement by the alternate pathway, even without prior forming an antigen-antibody complex?
4. IgA
5. IgD
6. IgE
7. IgG
8. IgM

ANS: A, IgA can activate complement by the alternate pathway.

4. Antigen-antibody reaction in polyarteritis nodosa is characterized by which form of necrosis of the arterial wall?
5. Coagulative necrosis
6. Fibrinoid necrosis
7. Liquefactive necrosis
8. Fat necrosis
9. Caseous necrosis

ANS: B, Antigen-antibody complexes cause inflammation of the vessel wall, accompanied by the insudation of plasma proteins into the site of injury. The necrosis is classified as fibrinoid, because it contains large amounts of fibrin formed from fibrinogen in the plasma insudated into the damaged vessel wall.