Lehne's Pharmacology for Nursing Care 9th Edition by Jacqueline Burchum
Lehne's Pharmacology for Nursing Care 9th Edition by Jacqueline Burchum
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Chapter 103: Anticancer Drugs II: Hormonal Agents, Targeted Drugs, and Other Noncytotoxic Anticancer Drugs
Complete Chapter Questions With Answers
Sample Questions Are Posted Below
MULTIPLE CHOICE
| a. | Antiestrogen drugs decrease the risk for thromboembolic events. |
| b. | Antiestrogen drugs increase the risk for endometrial cancer. |
| c. | Aromatase inhibitors block the production of estrogen by the ovaries. |
| d. | Aromatase inhibitors can be used for tumor cells that lack estrogen receptors. |
ANS: B
Antiestrogen drugs cause proliferation of endometrial tissue by acting as receptor agonists at receptors in the uterus. Antiestrogen drugs increase the risk of thromboembolic events. Aromatase inhibitors block the production of estrogen from androgenic precursors, not by the ovaries. Aromatase inhibitors are used to treat ER-positive breast cancer.
PTS: 1 DIF: Cognitive Level: Application REF: p. 1239 | p. 1242
TOP: Nursing Process: Implementation
MSC: NCLEX Client Needs Category: Physiologic Integrity: Pharmacologic and Parenteral Therapies
| a. | History of deep vein thrombosis (DVT) |
| b. | History of osteoporosis |
| c. | Hyperlipidemia |
| d. | Prior hysterectomy |
ANS: A
The patient’s age and DVT history place her at risk for thrombosis. Tamoxifen would not be indicated for this patient. A prior hysterectomy, osteoporosis, and hyperlipidemia are not contraindications to tamoxifen.
PTS: 1 DIF: Cognitive Level: Analysis REF: p. 1229
TOP: Nursing Process: Assessment
MSC: NCLEX Client Needs Category: Physiologic Integrity: Pharmacologic and Parenteral Therapies
| a. | Because of her family risk and late childbearing, this drug is a good choice for her. |
| b. | Her history of DVT outweighs any possible benefits she may have with this drug. |
| c. | Since she has not had a hysterectomy, the risk of endometrial cancer is too great. |
| d. | When she turns 50 years old, this drug will carry fewer risks for her. |
ANS: B
Tamoxifen is a good choice for women between the ages of 40 and 49 years as a cancer preventive, except for women at risk for DVT. Family risk and late childbearing age are indications for using tamoxifen, but only in women without increased risk of DVT. The risk of endometrial cancer increases with age and, without the risk of DVT, would not be a contraindication in a woman of the patient’s age. The patient’s risks of DVT do not change with age.
PTS: 1 DIF: Cognitive Level: Application REF: p. 1229
TOP: Nursing Process: Planning
MSC: NCLEX Client Needs Category: Physiologic Integrity: Pharmacologic and Parenteral Therapies
| a. | Anastrozole is more likely to cause hot flushes than tamoxifen. |
| b. | Anastrozole is more likely to promote endometrial carcinoma. |
| c. | Cancer recurrence is higher with anastrozole. |
| d. | Until she is postmenopausal, anastrozole will not be effective. |
ANS: D
Anastrozole is used to treat ER-positive breast cancer in postmenopausal women. Because it does not block estrogen production in the ovaries, it is not effective in premenopausal women. It may cause hot flushes but is less likely to do so than tamoxifen. It is devoid of all estrogenic activity and does not promote endometrial cancer
PTS: 1 DIF: Cognitive Level: Application REF: p. 1242
TOP: Nursing Process: Planning
MSC: NCLEX Client Needs Category: Physiologic Integrity: Pharmacologic and Parenteral Therapies
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