Chapter 13: Aerosolized Antiinfective Agents

Chapter 13: Aerosolized Antiinfective Agents

 

Complete Chapter Questions With Answers

 

Sample Questions Are Posted Below

 

MULTIPLE CHOICE

 

1. Pentamidine is

a.	a bactericidal agent.
b.	an antiprotozoal agent.
c.	an antiviral agent.
d.	an antibiotic.

 

 

ANS:  B

Pentamidine isethionate is an antiprotozoal agent that is effective against Pneumocystis carinii (jiroveci), the causative organism for Pneumocystis pneumonia (PCP). Although pentamidine is listed as an antiprotozoal agent, P. carinii (jiroveci) is a fungus.

 

REF:   pp. 220-223

 

2. Inhaled pentamidine is indicated for

a.	treatment of bronchospasm.
b.	bacterial pneumonia in cystic fibrosis patients.
c.	prevention of Pneumocystis pneumonia (PCP).
d.	treatment of respiratory syncytial virus (RSV).

 

 

ANS:  C

Inhaled pentamidine is active against P. carinii (jiroveci), the causative organism of PCP. Bronchospasm is a local airway effect with aerosol administration of pentamidine. Inhaled tobramycin is administered to manage Pseudomonas aeruginosa infections in patients with cystic fibrosis. Ribavirin is used to treat RSV infection.

 

REF:   pp. 220-223

 

3. The trade name for aerosolized pentamidine is

a.	Virazole.
b.	Atrovent.
c.	Flovent.
d.	NebuPent.

 

 

ANS:  D

NebuPent, the brand of pentamidine approved for inhalation as an aerosol, is supplied as a dry powder, with 300 mg in a single vial. Virazole is the brand name for ribavirin, Atrovent is the brand name for ipratropium bromide, and Flovent is the brand name for fluticasone propionate.

 

REF:   pp. 220-223

 

4. Pentamidine is administered by which of the following routes?
5. Inhaled aerosol
6. Intramuscular injection
7. Syrup
8. Tablet
9. Intravenous injection

 

a.	1 and 4 only
b.	1, 2, and 5 only
c.	2, 3, 4, and 5 only
d.	1, 2, 3, 4, and 5

 

 

ANS:  B

Pentamidine can be given either parenterally (intravenous or intramuscular injection) or as an inhaled aerosol, but it is not absorbed with oral administration.

 

REF:   pp. 220-223

 

5. The approved dose of pentamidine by aerosol for prevention of Pneumocystis carinii pneumonia (PCP) is

a.	300 mg once per week.
b.	300 mg once every 4 weeks.
c.	600 mg once every other month.
d.	600 mg once every 4 weeks.

 

 

ANS:  B

On the basis of information gathered during a prophylaxis trial conducted in San Francisco, the approved dose of aerosolized pentamidine for prophylaxis of PCP in patients with acquired immunodeficiency syndrome (AIDS) is 300 mg every 4 weeks.

 

REF:   pp. 220-223