Chapter 13: WBCS

Chapter 13: WBCS

Complete Chapter Questions With Answers

Sample Questions Are Posted Below

MULTIPLE CHOICE

1. A 15-year-old boy developed generalized lymphadenopathy, accompanied by fever and malaise. A lymph node biopsy specimen showed that the architecture of the lymph nodes was erased and the nodes were infiltrated with moderately large lymphoid cells. There were numerous mitoses and apoptotic bodies. Between the B lymphocytes, there were phagocytic macrophages, imparting a “starry-sky” appearance to the lymph node. Which of the following is the most likely diagnosis?
2. Follicular lymphoma
3. Large B-cell lymphoma
4. Chronic lymphocytic leukemia/small lymphocytic lymphoma
5. Burkitt lymphoma
6. Multiple myeloma

ANS: D, Burkitt lymphoma presents with diffuse infiltration of the lymph nodes. There are many mitoses, apoptotic bodies, and macrophages that impart a starry-sky appearance to the lymph node.

2. Terminal deoxynucleotidyltransferase is a marker of
3. B cells
4. T cells
5. Precursors of B and T lymphocytes
6. Plasma cells
7. Natural killer cells

ANS: C, Terminal deoxynucleotidyltransferase, a specialized DNA polymerase, is expressed on undifferentiated pre-B and pre-T lymphoblasts. It is typically found in more than 95% of cases of acute lymphoblastic leukemia of the precursor B-cell and T-cell type.

3. Transformation of chronic lymphocytic leukemia or small cell lymphocytic lymphoma into a large B-cell lymphoma is called
4. Burkitt lymphoma
5. Waldenstrom macroglobulinemia
6. Richter syndrome
7. myelodysplastic syndrome
8. mycosis fungoides

ANS: C, Terminal transformation of low-grade lymphoma/leukemia into high-grade lymphoblastic lymphoma is called Richter syndrome. It occurs in 10% of patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).