Chapter 14: RBCS

Chapter 14: RBCS

Complete Chapter Questions With Answers

Sample Questions Are Posted Below

MULTIPLE CHOICE

1. Which is the most common cause of microcytic hypochromic anemia in American women aged 20 to 50 years?
2. Autoimmune hemolysis
3. Iron deficiency
4. Vitamin B₁₂ deficiency
5. Thalassemia minor
6. Viral infection

ANS: B, Iron deficiency resulting from the monthly loss of iron in menstrual blood is the most common cause of microcytic hypochromic anemia.

2. The most common form of autosomal dominant hereditary spherocytosis is caused by a mutation of the gene encoding which of the following proteins?
3. Ankyrin
4. Spectrin
5. Protein 4.1
6. Hemoglobin A
7. Transferrin

ANS: A, The most common form of autosomal dominant hereditary spherocytosis is caused by a mutation of the ankyrin gene. However, a deficiency of spectrin, which may be primary or secondary due to another defect, is found in most forms of hereditary spherocytosis, making it the most common biochemical abnormality in this disease.

3. Aplastic crisis, which can be encountered in patients with hereditary spherocytosis or sickle cell anemia, is most often precipitated by
4. deficiency of erythropoietin
5. negative feedback inhibition by bilirubin
6. adverse effect of iron released from hemolyzed erythrocytes
7. autoimmune mechanisms
8. parvovirus infection

ANS: E, Aplastic crisis in hereditary spherocytosis or sickle cell anemia is usually triggered by parvovirus infection. The virus infects and destroys the red blood cell precursors in the bone marrow.

4. The deletion of two α-globin chains of hemoglobin is the cause of
5. α-thalassemia trait
6. α-thalassemia minor
7. salient carrier state
8. hemoglobin H disease
9. hydrops fetalis

ANS: A, Deletion of two a-globin genes is found in patients who have a-thalassemia trait. These patients, like those who have ß-thalassemia minor, are asymptomatic.