Chapter 18: Liver

Chapter 18: Liver

Complete Chapter Questions With Answers

Sample Questions Are Posted Below

MULTIPLE CHOICE

1. A mutation of the gene encoding the hepatic enzyme bilirubin uridine diphosphate– glucuronosyltransferase (UGT1A1) associated with congenital jaundice and a complete absence of UGT1A1 is called
2. Crigler-Najjar syndrome type I
3. Gilbert disease
4. Dubin-Johnson disease
5. Rotor syndrome
6. Galactosemia

ANS: A, Crigler-Najjar syndrome type I is an autosomal recessive form of jaundice that is lethal in early infancy. It is caused by the mutation of the gene coding the bilirubin uridine diphosphate–glucoronsyltransferase (UGT), in which this enzyme is completely absent.

2. Which genetic liver disease results from the mutation of multidrug resistance protein 2 (MRP2) and is characterized by massive accumulation of pigmentary granules in hepatocytes and dark discoloration of the liver?
3. Crigler-Najjar syndrome type I
4. Gilbert disease
5. Dubin-Johnson disease
6. Rotor syndrome
7. Galactosemia

ANS: C, Dubin-Johnson syndrome, a mutation of multidrug resistance protein 2 (MRP2) affecting the canalicular transport of bilirubin in the liver, is characterized by an accumulation of dark pigment causing black discoloration of the liver.

3. Transplacental infection of the fetus will most often occur in women who have been infected with which hepatotropic virus?
4. Hepatitis A virus (HAV)
5. HBV
6. HCV
7. HDV
8. HEV

ANS: B, Hepatitis B virus B (HBV) is readily transmitted across the placenta from the

mother to the fetus. Transmission of HCV can also occur across the placenta, but this seldom occurs.

4. Cryoglobulinemia is found in chronic hepatitis caused by which hepatotropic virus?
5. Hepatitis A virus (HAV)
6. HBV
7. HCV
8. HDV
9. HEV

ANS: C, Cryoglobulinemia is found in a significant number of patients who have chronic hepatitis C virus (HCV).