Chapter 27: Nerve and Muscle

Chapter 27: Nerve and Muscle

Complete Chapter Questions With Answers

Sample Questions Are Posted Below

MULTIPLE CHOICE

1. Guillain-Barré syndrome is mediated by which form of immune hypersensitivity reaction?
2. Atopic IgE–mediated reaction
3. Cytotoxic IgG antibody–mediated reaction
4. Circulating immune complex–mediated reaction
5. T cell–mediated reaction
6. Graft-versus-host reaction

ANS: D, Guillain-Barré syndrome is mediated by T cells that stimulate macrophages to cause demyelination of myelinated nerves.

2. Trinucleotide CTG repeat expansion plays a role in the pathogenesis of which of the following muscle diseases?
3. Duchenne muscular dystrophy
4. Becker muscular dystrophy
5. Autosomal dominant limb girdle muscular dystrophy
6. Autosomal recessive limb girdle muscular dystrophy
7. Myotonic dystrophy

ANS: E, The trinucleotide CTG repeat expansion on chromosome 19q13.2-13.3 affecting the dystrophia myotonia-protein kinase gene is the genetic basis of myotonic dystrophy.

3. Which of the following muscle diseases is classified as an ion channel myopathy (channelopathy)?
4. Dysferlin deficiency
5. Becker muscular dystrophy
6. Malignant hyperpyrexia
7. Central core disease
8. Myotubular myopathy

ANS: C, Malignant hyperpyrexia (malignant hyperthermia) is characterized by a hypermetabolic state (tachycardia, tachypnea, muscle spasm, and high fever) that is triggered by induction of anesthesia. Several mutations have been identified in these patients, including an L-type voltage–dependent calcium channel. Hence, this disease is classified as a channelopathy.