Pathophysiology The Biologic Basis for Disease in Adults and Children, 7th Edition by Kathryn L.
Pathophysiology The Biologic Basis for Disease in Adults and Children, 7th Edition by Kathryn L.
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Chapter 29: Alterations of Leukocyte, Lymphoid, and Hemostatic Function
Complete Chapter Questions With Answers
Sample Questions Are Posted Below
MULTIPLE CHOICE
| a. | Neutrophilia | c. | Eosinophilia |
| b. | Basophilia | d. | Monocytosis |
ANS: C
Eosinophilia is an absolute increase (more than 450/µL) in the total numbers of circulating eosinophils. Allergic disorders (type I hypersensitivity) associated with asthma, hay fever, and drug reactions, as well as parasitic infections (particularly with metazoal parasites), are often cited as causes. This change is not identified by any of other options.
PTS: 1 REF: Pages 1010-1011
| a. | Immunoglobulin E (IgE) | c. | Immunoglobulin G (IgG) |
| b. | Immunoglobulin M (IgM) | d. | Immunoglobulin A (IgA) |
ANS: B
Heterophile antibodies are a heterogeneous group of IgM antibodies that are agglutinins against nonhuman red blood cells (e.g., sheep, horse) and are detected by qualitative (monospot) or quantitative (heterophile antibody) test methods. This statement is not true of the other options.
PTS: 1 REF: Pages 1012-1013
| a. | ALL is a progressive neoplasm defined by the presence of greater than 30% lymphoblasts in the bone marrow or blood. |
| b. | Leukocytosis and a predominance of blast cells characterize the bone marrow and peripheral blood. As the immature blasts increase, they replace normal myelocytic cells, megakaryocytes, and erythrocytes. |
| c. | B cells fail to mature into plasma cells that synthesize immunoglobulins. |
| d. | The translocation of genetic material from genes 9 and 22 create an abnormal, fused gene identified as BCR-ABL. |
ANS: A
ALL is a progressive neoplasm defined by the presence of greater than 30% lymphoblasts in the bone marrow or blood. None of the other options provide an accurate description of ALL.
PTS: 1 REF: Page 1016
| a. | Defects exist in the ras oncogene, TP53 tumor-suppressor gene, and INK4A, the gene encoding a cell-cycle regulatory protein. |
| b. | Leukocytosis and a predominance of blast cells characterize the bone marrow and peripheral blood. As the immature blasts increase, they replace normal myelocytic cells, megakaryocytes, and erythrocytes. |
| c. | B cells fail to mature into plasma cells that synthesize immunoglobulins. |
| d. | The translocation of genetic material from genes 9 and 22 creates an abnormal, fused protein identified as BCR-ABL1. |
ANS: D
The Philadelphia chromosome is present in more than 95% of those with CML, and the presence of the BCR-ABL1 protein is responsible for the initiation of CML. The other options do not accurately describe CML.
PTS: 1 REF: Pages 1014-1015 | Page 1021
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