Chapter 3: How drugs act: molecular aspects

Chapter 3: How drugs act: molecular aspects

Complete Chapter Questions With Answers

Sample Questions Are Posted Below

MULTIPLE CHOICE

1. The Jak/Stat pathway of signal transduction responds to activation by

1. 1. acetylcholine
   2. steroid hormones
   3. human growth hormone
   4. cytokines
   5. epinephrine

Answer d: cytokines

1. In the growth factor kinase cascade, Map (mitogen-activated protein) kinase acts to phosphorylate

1. 1. DNA
   2. transcription factors
   3. cyclic AMP
   4. ion channels
   5. transport proteins

Answer b: transcription factors

1. Which second messenger in a G-protein coupled receptor signal transduction cascade typically increases intracellular calcium?

1. 1. cyclic GMP
   2. cyclic AMP
   3. diacylglycerol
   4. arachidonic acid
   5. inositol triphosphate

Answer e: inositol triphosphate

1. Which signal transduction pathway is most important in cell division, growth, and differentiation?

1. 1. beta-adrenoceptor signal pathways
   2. phospholipase C pathways
   3. Ras/Raf/Map kinase
   4. eicosanoid signal pathways
   5. guanylate cyclic signal pathways

Answer c: Ras/Raf/Map kinase

1. Coupling of a G-protein alpha subunit to an agonist-occupied receptor initially leads to

1. 1. activation of the beta-gamma complex
   2. hydrolysis of GTP
   3. activation of adenylate cyclase
   4. exchange of bound GDP with GTP
   5. dissociation of the alpha-subunit from the receptor

Answer d: exchange of bound GDP with GTP