Chapter 31: Drug Therapy for Male Reproductive Problems

Chapter 31: Drug Therapy for Male Reproductive Problems

 

Complete Chapter Questions With Answers

 

Sample Questions Are Posted Below

 

MULTIPLE CHOICE

 

BASIC CONCEPTS

 

1. How do DHT inhibitors work to reduce benign prostatic hyperplasia?

a.	Relaxing the muscles of the bladder.
b.	Increasing urine production.
c.	Shrinking the prostate gland.
d.	Relaxing prostate smooth muscle.

 

 

ANS:  C

DHT inhibitors work directly on the prostate gland. They are a “counterfeit” drug that looks like testosterone and binds to the enzyme that normally converts testosterone to DHT, its most powerful form. This counterfeit drug cannot be converted to DHT; and, while it is bound to the enzyme, the enzyme is not available to convert the real testosterone to DHT. With much less DHT in the prostate, the cells in the prostate gland do not receive the signal to grow. As a result, the gland shrinks and puts less pressure on the urethra, allowing better urine flow.

 

DIF:    Cognitive Level: Remembering        REF:   p. 483

 

2. Which drug belongs to the DHT inhibitor class?

a.	Alfuzosin
b.	Tamsulosin
c.	Silodosin
d.	Dutasteride

 

 

ANS:  D

Alfuzosin, tamsulosin, and silodosin are all selective alpha-1 blockers. Dutasteride and finasteride are DHT inhibitors.

 

DIF:    Cognitive Level: Remembering        REF:   p. 483

 

3. Which side effect is caused by selective alpha-1 blockers for benign prostatic hyperplasia?

a.	Low blood pressure
b.	Male-pattern baldness
c.	Erectile dysfunction
d.	Urinary retention

 

 

ANS:  A

Selective alpha-1 blockers can lower blood pressure, especially when changing positions (orthostatic hypotension), causing dizziness or light-headedness.

 

DIF:    Cognitive Level: Remembering        REF:   p. 483

 

4. What is the most common side effect of drugs used for benign prostate hypertrophy (BPH)?

a.	Low blood pressure
b.	Decreased libido
c.	Light-headedness
d.	Hair loss

 

 

ANS:  B

Side effects of drugs used for BPH also include erectile dysfunction, decreased seminal fluid, and reduced fertility. The most common side effect of these drugs is a decreased interest in sexual activity.

 

DIF:    Cognitive Level: Remembering        REF:   p. 483

 

5. Which test or examination does a patient receive before taking any drug for benign prostate hypertrophy (BPH)?

a.	Digital rectal examination
b.	24-hour urinalysis
c.	Kidney function test
d.	Urine culture

 

 

ANS:  A

The signs and symptoms of BPH are the same as for prostate cancer. Before a drug for BPH is taken, the patient should have a digital rectal examination by his prescriber and have his blood tested for prostate-specific antigen levels to rule out prostate cancer.

 

DIF:    Cognitive Level: Remembering        REF:   p. 484