Pharmacology For the Primary Care Provider 4th Edition by Edmunds Mayhew
Pharmacology For the Primary Care Provider 4th Edition by Edmunds Mayhew
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Chapter 38: Gout Medications
Complete Chapter Questions With Answers
Sample Questions Are Posted Below
MULTIPLE CHOICE
| a. | prescribe colchicine. |
| b. | discontinue the thiazide diuretic. |
| c. | order a 24-hour urine collection. |
| d. | refer the patient to a rheumatologist. |
ANS: C
Patients who have hypertension or who take thiazide diuretics are at increased risk for gout. An elevated uric acid level alone is not diagnostic, and a 24-hour urine collection should be ordered. Colchicine should not be prescribed until the diagnosis is confirmed. It is not necessary to discontinue the thiazide diuretic. A referral to a specialist is not indicated.
DIF: Cognitive Level: Applying (Application) REF: 423
| a. | renal function tests. |
| b. | serum uric acid levels. |
| c. | 24-hour urine collection. |
| d. | synovial fluid aspirate for Gram stain and culture. |
ANS: D
Although the other tests are part of the diagnostic process, the most important differential diagnosis to be made in a patient with gout is the exclusion of a septic joint.
DIF: Cognitive Level: Applying (Application) REF: 423
| a. | febuxostat (Uloric). |
| b. | colchicine (Colcrys). |
| c. | allopurinol (Zyloprim). |
| d. | probenecid (Benemid). |
ANS: D
A uricosuric agent is indicated to increase the excretion of uric acid. Probenecid is a uricosuric medication. Febuxostat and allopurinol are xanthine oxidase inhibitors. Colchicine is not a uricosuric agent.
DIF: Cognitive Level: Applying (Application) REF: 423
| a. | ask the patient about fluid intake. |
| b. | order a urinalysis and urine culture. |
| c. | change the medication to allopurinol. |
| d. | recommend nonsteroidal antiinflammatory drugs (NSAIDs) to treat flank pain. |
ANS: A
Uricosuric agents are tubular blocking agents and decrease serum uric acid levels by increasing urinary excretion of uric acid. During this process, high concentrations of uric acid develop in the proximal renal tubules and may predispose the patient to the development of urinary stones. Patients should be encouraged to drink plenty of fluids. The patient who presents with flank pain should be questioned about fluid intake. If fluid intake is sufficient and renal stones are ruled out, a urinary tract infection may be considered. Allopurinol is not indicated. NSAIDs are not indicated.
DIF: Cognitive Level: Applying (Application) REF: 423
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