Pathophysiology, 5th Edition By Lee-Ellen C. Copstead
Pathophysiology, 5th Edition By Lee-Ellen C. Copstead
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Chapter 39: Endocrine Physiology and Mechanisms of Hypothalamic-Pituitary Regulation
Complete Chapter Questions With Answers
Sample Questions Are Posted Below
MULTIPLE CHOICE
| a. | transported in a free state in the bloodstream. |
| b. | bound to receptors on the plasma membranes of target cells. |
| c. | diffused through cell membranes to activate intracellular receptors. |
| d. | activated by second-messenger cascades within the target cell. |
ANS: C
Once formed, lipid-soluble hormones simply diffuse through the plasma membrane and into the circulation. Lipid-soluble hormones are diffused through the plasma membrane for release into the circulation. Lipid-soluble hormones are not bound to receptors for release to target cells. Second-messenger cascades are not required for activation of lipid-soluble hormones.
REF: Pgs. 786-787
| a. | catecholamine. |
| b. | thyroid hormone. |
| c. | peptide hormone. |
| d. | pituitary hormone. |
ANS: B
Thyroid hormones are lipid-soluble. Catecholamines and peptide hormones are water-soluble. Peptide hormones are released from the pituitary gland.
REF: Pgs. 786-787
| a. | pituitary hyposecretion of TSH. |
| b. | adrenal insufficiency following adrenalectomy. |
| c. | congenital adrenal hyperplasia. |
| d. | pheochromocytoma. |
ANS: A
Secondary endocrine disorder occurs when secretion of a tropic hormone such as TSH or ACTH is inadequate to cause the target gland to secrete adequate amounts of hormone. Primary hyposecretion occurs when an endocrine gland, such as the thyroid or adrenal cortex, releases an inadequate amount of hormone to meet physiologic needs. Congenital adrenal hyperplasia is an example of a hypersecretion disorder. Pheochromocytoma is not a secondary endocrine disorder.
REF: Pgs. 797-798
| a. | decreased target cell sensitivity to hormone. |
| b. | reduced production of hormone. |
| c. | increased target cell responsiveness to hormone. |
| d. | an increased hormone half-life. |
ANS: C
Up-regulation would make the cell more sensitive to the hormone, and hormone-dependent cellular activity could occur at normal or nearly normal levels despite a lower than normal hormone concentration. Down-regulation would result in decreased target cell sensitivity. A reduction in hormone production does not occur with up-regulation. Up-regulation of target cell receptors does not result in an increased hormone half-life.
REF: Pg. 788
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