Chapter 39: Neurodegenerative diseases

Chapter 39: Neurodegenerative diseases

Complete Chapter Questions With Answers

Sample Questions Are Posted Below

MULTIPLE CHOICE

1. An essential factor in neuronal excitotoxicity is

1. depletion of intracellular calcium
2. excessive levels of intracellular calcium
3. depletion of adenosine triphosphate
4. inhibition of intracellular proteases
5. depletion of intracellular glutamate

Answer b: excessive levels of intracellular calcium

1. The accumulation of b-amyloid protein is believed to cause neuronal degeneration in

1. Huntington’s disease
2. Parkinson’s disease
3. Creutzfeldt-Jakob disease
4. amyotrophic lateral sclerosis
5. Alzheimer’s disease

Answer e: Alzheimer’s disease

1. Levodopa is usually administered with a peripheral dopa decarboxylase inhibitor such as

1. carbidopa
2. selegiline
3. entacapone
4. amantadine
5. pergolide

Answer a: carbidopa

1. Factors that contribute to the development of Alzheimer’s disease include

1. absence of Ab40 peptides
2. decreased proportion of Ab42 peptides
3. mutations in the apoE4 gene
4. increased expression of a-secretase
5. decreased expression of g-secretase

Answer c: mutations in the apoE4 gene