Basic Pharmacology For Nurses,15th Edition by Bruce D. Clayton
Basic Pharmacology For Nurses,15th Edition by Bruce D. Clayton
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Chapter 44: Drugs Used for Cancer Treatment
Complete Chapter Questions With Answers
Sample Questions Are Posted Below
MULTIPLE CHOICE
| A. | “Combination chemotherapy is the administration of an antineoplastic drug that will be toxic during a specific phase of cellular growth.” |
| B. | “Combination chemotherapy is the administration of an antineoplastic drug that is active throughout the cell cycle.” |
| C. | “Combination chemotherapy is the administration of antineoplastic drugs that change the way the body responds to cancer or strengthens the immune system.” |
| D. | “Combination chemotherapy is the administration of antineoplastic drugs, which results in cell death during different phases of the cell cycle.” |
ANS: D
| Feedback | |
| A | This is a single drug regimen, not a combination. |
| B | This is a single drug regimen, not a combination. |
| C | This is a single drug regimen, not a combination. |
| D | Use of combination drug therapy is superior in therapeutic effect to the use of single-agent chemotherapy. |
DIF: Cognitive Level: Comprehension REF: 697
TOP: Nursing Process Step: Implementation
MSC: NCLEX Client Needs Category: Physiological Integrity
| A. | S phase |
| B. | Mitotic phase |
| C. | Phase G1 |
| D. | Phase G0 |
ANS: B
| Feedback | |
| A | The S phase is the stage of active synthesis of two sets of DNA. |
| B | Vinca alkaloids block the formation of the mitotic spindle during mitosis, thus inhibiting cell division. |
| C | Phase G1 is considered a presynthetic phase in which the cell prepares for DNA synthesis by manufacturing necessary enzymes. |
| D | G0 is the largest variable in the cell cycle and, during this resting phase, the cell is not actively replicating. |
DIF: Cognitive Level: Knowledge REF: 705
TOP: Nursing Process Step: Implementation
MSC: NCLEX Client Needs Category: Physiological Integrity
| A. | Ongoing proliferation of neoplastic tissue |
| B. | The known cellular kinetics of the neoplasm |
| C. | The hormonal requirements of the patient |
| D. | The body’s response in strengthening the immune system |
ANS: B
| Feedback | |
| A | The object of chemotherapy is to stop the proliferation of neoplastic tissue. |
| B | Cell cycle–specific agent scheduling should be correlated with the known cellular kinetics of the particular type of neoplasm being treated. This type of drug is schedule-dependent and selectively toxic when the cell is in a specific phase of growth. |
| C | Hormones are only used in specific types of cancer and are not related to cell cycle specificity. |
| D | Immunomodulators are used to enhance the body’s response in strengthening the immune system. |
DIF: Cognitive Level: Comprehension REF: 689
TOP: Nursing Process Step: Implementation
MSC: NCLEX Client Needs Category: Physiological Integrity
| A. | Resting phases |
| B. | Rapid division |
| C. | Remission intervals |
| D. | Slow replication |
ANS: B
| Feedback | |
| A | Cancer cells are not sensitive to chemotherapy during resting phases. |
| B | The cancer cells are the most sensitive to chemotherapy when the cells are dividing rapidly. |
| C | Cancer cells are not sensitive to chemotherapy during remission intervals. |
| D | Cancer cells are not sensitive to chemotherapy during slow replication. |
DIF: Cognitive Level: Knowledge REF: 697
TOP: Nursing Process Step: Implementation
MSC: NCLEX Client Needs Category: Physiological Integrity
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