Basic Pharmacology for Nurses 16th Ed by Clayton - Willihnganz
Basic Pharmacology for Nurses 16th Ed by Clayton - Willihnganz
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Chapter 44: Drugs Used for Cancer Treatment
Complete Chapter Questions With Answers
Sample Questions Are Posted Below
MULTIPLE CHOICE
| a. | “Combination chemotherapy is the administration of an antineoplastic drug that will be toxic during a specific phase of cellular growth.” |
| b. | “Combination chemotherapy is the administration of an antineoplastic drug that is active throughout the cell cycle.” |
| c. | “Combination chemotherapy is the administration of antineoplastic drugs that change the way the body responds to cancer or strengthens the immune system.” |
| d. | “Combination chemotherapy is the administration of antineoplastic drugs, which results in cell death during different phases of the cell cycle.” |
ANS: D
Use of combination drug therapy is superior in therapeutic effect to the use of single agent chemotherapy.
DIF: Cognitive Level: Comprehension REF: p. 699 OBJ: 5
TOP: Nursing Process Step: Implementation
MSC: NCLEX Client Needs Category: Physiological Integrity
| a. | S phase |
| b. | Mitotic phase |
| c. | Phase G1 |
| d. | Phase G0 |
ANS: B
Vinca alkaloids block the formation of the mitotic spindle during mitosis, thus inhibiting cell division. The S phase is the stage of active synthesis of two sets of DNA. Phase G1 is considered a presynthetic phase in which the cell prepares for DNA synthesis by manufacturing necessary enzymes. G0 is the largest variable in the cell cycle and, during this resting phase, the cell is not actively replicating.
DIF: Cognitive Level: Knowledge REF: p. 698 OBJ: 3
TOP: Nursing Process Step: Implementation
MSC: NCLEX Client Needs Category: Physiological Integrity
| a. | Ongoing proliferation of neoplastic tissue |
| b. | The known cellular kinetics of the neoplasm |
| c. | The hormonal requirements of the patient |
| d. | The body’s response in strengthening the immune system |
ANS: B
Cell cycle–specific agent scheduling should be correlated with the known cellular kinetics of the particular type of neoplasm being treated. This type of drug is schedule dependent and selectively toxic when the cell is in a specific phase of growth. The object of chemotherapy is to stop the proliferation of neoplastic tissue. Hormones are only used in specific types of cancer and are not related to cell cycle specificity. Immunomodulators are used to enhance the body’s response in strengthening the immune system.
DIF: Cognitive Level: Comprehension REF: pp. 698-699 OBJ: 3
TOP: Nursing Process Step: Implementation
MSC: NCLEX Client Needs Category: Physiological Integrity
| a. | Resting phases |
| b. | Rapid division |
| c. | Remission intervals |
| d. | Slow replication |
ANS: B
The cancer cells are the most sensitive to chemotherapy when the cells are dividing rapidly. Cancer cells are not sensitive to chemotherapy during resting phases, remission intervals, or slow replication.
DIF: Cognitive Level: Knowledge REF: p. 699 OBJ: 5
TOP: Nursing Process Step: Implementation
MSC: NCLEX Client Needs Category: Physiological Integrity
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