Chapter 48: Drug addiction, dependence, and abuse

Chapter 48: Drug addiction, dependence, and abuse

Complete Chapter Questions With Answers

Sample Questions Are Posted Below

MULTIPLE CHOICE

1. All dependence-producing drugs act via different pathways to cause

1. depletion of norepinephrine in the locus coeruleus
2. depletion of dopamine in nigrostriatal pathways
3. depletion of glutamate in meso-limbic pathways
4. the release of glutamate in the frontal cortex
5. the release of dopamine in the nucleus accumbens

Answer e: the release of dopamine in the nucleus accumbens

1. Chronic administration of morphine is believed to cause tolerance by

1. increasing expression of adenylate cyclase
2. decreasing expression of adenylate cyclase
3. increasing expression of guanylate cyclase
4. decreasing expression of guanylate cyclase
5. increasing expression of a-adrenoceptors

Answer a: increasing expression of adenylate cyclase

1. Nicotine use often leads to drug dependence by activation of nicotinic receptors in the

1. nucleus accumbens
2. hippocampus
3. ventral tegmental area
4. cerebral cortex
5. striatum

Answer c: ventral tegmental area

1. Disulfiram has been used to facilitate abstinence from ethanol based on its ability to inhibit

1. the mesolimbic dopaminergic pathway
2. ethanol withdrawal symptoms
3. alcohol dehydrogenase
4. aldehyde dehydrogenase
5. aldehyde oxidase

Answer d: aldehyde dehydrogenase