Chapter 56: Drugs for Breast Cancer

Pharmacology For the Primary Care Provider 4th Edition by Edmunds Mayhew

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Chapter 56: Drugs for Breast Cancer

 

Complete Chapter Questions With Answers

 

Sample Questions Are Posted Below

 

MULTIPLE CHOICE

 

  1. A woman who is being treated with radiotherapy for breast cancer asks her primary care nurse practitioner (NP) about using dietary supplements to improve her chance of recovery. The NP should tell her that:
a. vitamin E is not harmful but has not been shown to change outcomes.
b. no supplements have been shown to alter outcomes or response to therapy.
c. folic acid and other B vitamins may improve ability to tolerate chemotherapy.
d. vitamin C, taken at least 6 days per week, may lower her risk of cancer recurrence.

 

 

ANS:  D

Women with early-stage breast cancer who took supplements of vitamin C or vitamin E at least 6 days per week had a lower risk of cancer recurrence with vitamin C but no differences with vitamin E. B vitamins are not listed as effective.

 

DIF:    Cognitive Level: Understanding (Comprehension)             REF:   647

 

  1. A postmenopausal woman has metastatic breast cancer that is estrogen receptor negative. She is scheduled to begin chemotherapy the following week and asks her primary care NP what other medications her oncologist may prescribe to treat her cancer. The NP should expect the oncologist to prescribe:
a. toremifene (Fareston).
b. tamoxifen (Nolvadex).
c. fulvestrant (Faslodex).
d. anastrozole (Arimidex).

 

 

ANS:  D

Anastrozole (Arimidex) is a selective aromatase inhibitor and is useful in postmenopausal women who have estrogen receptor–negative breast cancer. The other medications are antiestrogens and treat estrogen receptor–positive cancer.

 

DIF:    Cognitive Level: Applying (Application)                           REF:   648

 

  1. A primary care NP sees a 60-year-old woman for a physical examination. The woman tells the NP she is taking tamoxifen for treatment of breast cancer. To monitor her response to this medication, the NP should order:
a. a chest radiograph.
b. bone mineral density testing.
c. serum bilirubin and creatinine.
d. liver enzymes and a complete blood count (CBC).

 

 

ANS:  D

Patients taking antiestrogens, such as tamoxifen, should have periodic monitoring of liver enzymes and a CBC. A chest radiograph is not indicated. Bilirubin, creatinine, and bone mineral density testing are part of routine testing for patients taking aromatase inhibitors.

 

DIF:    Cognitive Level: Applying (Application)                           REF:   648

 

  1. A 50-year-old woman who is postmenopausal is taking an aromatase inhibitor as part of a breast cancer treatment regimen. She calls her primary care NP to report that she has had hot flashes and increased vaginal discharge but no bleeding. The NP should:
a. schedule her for a gynecologic examination.
b. recommend that she use a barrier method of contraception.
c. tell her to stop taking the medication and call her oncologist.
d. reassure her that these are normal side effects of the medication.

 

 

ANS:  A

Any abnormal vaginal discharge should be reported immediately and should be evaluated with a gynecologic examination to rule out carcinoma. She is not showing signs of ovulation, so contraception is not necessary. She should not stop taking the medication unless the gynecologic examination is positive. These are common side effects but are not always normal.

 

DIF:    Cognitive Level: Applying (Application)                           REF:   648

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