Chapter 56: Individual variation and drug interaction

Chapter 56: Individual variation and drug interaction

Complete Chapter Questions With Answers

Sample Questions Are Posted Below

MULTIPLE CHOICE

1. In babies born at term, the ability to conjugate drugs with glucuronate reaches adult levels in about

1. one week
2. one month
3. 8 weeks
4. 6 months
5. 1 year

Answer c: 8 weeks

1. The bimodal distribution of plasma isoniazid concentrations in a typical human population is the result of a genetically determined variation in

1. acetyltransferase activity
2. glucuronyl transferase activity
3. cytochrome P450 enzymes
4. plasma cholinesterase activity
5. plasma protein binding

Answer a: acetyltransferase activity

1. Carbamazepine may cause acute porphyria in susceptible persons because the drug

1. inhibits porphyrin excretion
2. increases porphyrin excretion
3. induces d-amino levulinic acid synthase
4. inhibits d-amino levulinic acid synthase
5. induces cytochrome P450 enzymes

Answer c: induces d-amino levulinic acid synthase