Chapter 9: Drug metabolism and elimination

Chapter 9: Drug metabolism and elimination

Complete Chapter Questions With Answers

Sample Questions Are Posted Below

MULTIPLE CHOICE

1. Hepatic cytochrome P450 drug-metabolizing enzymes are primarily found in

1. cell nuclei
2. plasma membranes
3. the cytoplasm
4. the smooth endoplasmic reticulum
5. mitochondria

Answer d: the smooth endoplasmic reticulum

1. Phase II drug metabolism

1. includes hydrolytic reactions
2. produces low molecular weight products
3. usually forms inactive metabolites
4. takes place mainly in the kidneys
5. requires NADPH as a cofactor

Answer c: usually forms inactive metabolites

1. Ketoconazole produces non-competitive inhibition of cytochrome P450 by

1. binding to the ferric form of heme iron
2. binding to the active site of the enzyme
3. causing enzyme autolysis
4. oxidizing NADPH
5. binding covalently to the P450 protein

Answer a: binding to the ferric form of heme iron

1. In first-order drug elimination

1. drug half-life is directly proportional to drug concentration
2. the rate of elimination is directly proportional to drug concentration
3. drug clearance is directly proportional to plasma drug concentration
4. the rate of elimination is constant
5. the rate of elimination is unpredictable

Answer b: the rate of elimination is directly proportional to drug concentration