Rang & Dale’s Pharmacology by Humphrey P. Rang – Test Bank

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Rang: Rang & Dale’s Pharmacology, 7^th Edition

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Chapter 5: Cell proliferation, apoptosis, repair and regeneration

MULTIPLE CHOICE

1. In the death receptor pathway, activation of tumor necrosis factor receptors causes the receptors to trimerize and complex an adapter protein, thereby leading to activation of

1. mitochondrial pathways
2. caspase-8
3. pro-apoptotic factor Bcl-2
4. a p53 protein
5. DNA transcription factors

Answer b: caspase-8

1. The activation of primitive stem cells so as to replace a damaged tissue is called

1. healing
2. repair
3. restoration
4. regeneration
5. rejuvenation

Answer d: regeneration

1. Defective apoptosis may contribute to the development of

1. cancer
2. Alzheimer’s disease
3. myocardial infarction
4. aplastic anemia
5. stroke

Answer a: cancer

1. The activation of caspase-3 leads to

1. activation of transcription factors
2. inhibition of transcription factors
3. activation of the anti-apoptotic pathway
4. fragmentation of genomic DNA
5. stabilization of cell membranes

Answer d: fragmentation of genomic DNA

1. Bortemozib causes accumulation of an apoptotic-promoter protein by inhibiting

1. mitochondrial DNA
2. suvivin
3. matrix metalolproteinases
4. pro-apoptotic Bcl-2
5. the proteasome

Answer e: the proteasome

1. Matrix metalloproteinases are responsible for

1. inhibition of neoplastic cell growth
2. adjusting the cell cytoskeleton
3. degradation of extracellular matrix
4. initiating angiogenesis
5. activation of the cell cycle

Answer c: degradation of extracellular matrix

1. Antisense compounds active against antiapoptotic factors are potentially useful for treating

1. myocardial infarction
2. leukemia
3. Parkinson’s disease
4. multiple sclerosis
5. impaired wound healing

Answer b: leukemia

1. Bevacizumab is a monoclonal antibody that targets

1. caspase-3
2. metalollproteinase
3. cyclin
4. vascular endothelial growth factor
5. promoters of apoptosis

Answer d: vascular endothelial growth factor

1. Mitochondria participate in apoptosis by releasing

1. apoptotic protease activating factor
2. caspase-9
3. cytochrome c
4. p53 protein
5. inhibitors of apoptosis

Answer c: cytochrome c

1.  Progress through the cell cycle is stimulated by

1. cyclin-dependent kinases
2. phosphorylated Rb protein
3. check point factors
4. p53 protein
5. inhibitors of kinases

Answer a: cyclin-dependent kinases