Chapter 17: Neonatal and Pediatric Aerosolized Drug Therapy

Chapter 17: Neonatal and Pediatric Aerosolized Drug Therapy

 

Complete Chapter Questions With Answers

 

Sample Questions Are Posted Below

 

MULTIPLE CHOICE

 

1. The use of a drug in an age group for which there is a lack of FDA-approved dosing information is termed

a.	against the law.
b.	off-label.
c.	unapproved.
d.	orphan drug.

 

 

ANS:  B

The termed off-label is used to refer to drugs lacking U.S. Food and Drug Administration (FDA)–approved dosing information for a specific age group or condition. Off-label prescribing is a commonly used and accepted medical practice. Although these drugs do have FDA approval, it is for a different use than the one prescribed.

 

REF:   p. 288

 

2. Generally, neonatal and pediatric drug dosing with inhaled aerosols is based on

a.	body size.
b.	a target effect strategy.
c.	when side effects occur.
d.	achievement of a certain blood level.

 

 

ANS:  B

Generally, drug dosing with inhaled aerosols for neonatal and pediatric patients is not based on body size and blood level but rather on a target effect strategy with avoidance of toxicity.

 

REF:   p. 289

 

3. Which of the following affect penetration and deposition of an aerosol in neonatal and pediatric patients?
4. Inertial impaction
5. Particle size
6. Velocity
7. Sedimentation

 

a.	1, 2, 3, and 4
b.	1 and 2 only
c.	1, 2, and 3 only
d.	1 only

 

 

ANS:  A

The same mechanisms of aerosol penetration and deposition in the lung that were outlined in Chapter 3 apply to aerosol therapy in neonatal and pediatric patients. These include inertial impaction, a function of particle size and velocity, and gravitational settling (sedimentation), a function of mass and residence time.

 

REF:   p. 293

 

4. Which of the following does affect aerosol drug delivery in infants and children?
5. Airway diameter
6. Gender
7. Tidal volume and flow rate
8. Respiratory rate

 

a.	1 and 3 only
b.	2, 3, and 4 only
c.	1, 3, and 4 only
d.	1, 2, 3, and 4

 

 

ANS:  C

Functional and structural features of the infant lung that may affect aerosol delivery and deposition include tracheal diameter, tracheal length, tidal volume, respiratory rate, minute ventilation, dead space, and inspiratory flow rate.

 

REF:   p. 293