Chapter 7: Neoplasia

Chapter 7: Neoplasia

Complete Chapter Questions With Answers

Sample Questions Are Posted Below

MULTIPLE CHOICE
1. Proto-oncogenes
a. are the same as oncogenes.
b. are normal cellular genes that promote growth.
c. lead to abnormal tumor suppressor genes
d. result from severe mutational events.
ANS: B
Proto-oncogenes are normal cellular genes that promote growth. Proto-oncogenes are not the same as oncogenes, which are mutant
proto-oncogenes. They are different from tumor suppressor genes and do not alter tumor suppressor genes. Mutational events lead
to oncogenes, a mutated proto-oncogene.
REF: Pg. 120
2. Familial retinoblastoma involves the transmission of what from parent to offspring?
a. Mutant tumor suppressor gene
b. Cancer-causing virus
c. Oncogene
d. Extra chromosome
ANS: A
Familial retinoblastoma involves transmission of a mutant tumor-suppressor gene from parent to child. Familial retinoblastoma is
not caused by a virus and does not involve an extra chromosome, but rather a single gene. Familial retinoblastoma is caused by a
mutant tumor suppressor gene, not an oncogene, which is a mutated proto-oncogene.
REF: Pg. 123
3. Your patient eats “lots of fat,” leads a “stressful” life, and has smoked “about two packs a day for the last 40 years.” Her chronic
morning cough recently worsened, and she was diagnosed with a lung mass. The most likely contributing factor for development of
lung cancer in this patient is
a. high-fat diet.
b. urban pollutants.
c. stressful lifestyle.
d. cigarette smoking.
ANS: D
The most likely contributing factor for the development of lung cancer is cigarette smoking. Tobacco smoke contains hundreds of
compounds, many of which have known genotoxicity and probably serve as initiators. Tobacco smoke also contains promoters,
which spur the mutant cells to proliferate. Although a high-fat diet, urban pollutants, and a stressful lifestyle have been implicated
in some types of cancer, they are not the likely contributing factor in your patient’s lung cancer.
REF: Pg. 116
4. After bronchoscopy and histologic examination of a suspected tumor, your patient is diagnosed with primary bronchial carcinoma.
Thus, the tumor
a. is benign.
b. is malignant.
c. is secondary to cancer elsewhere in the body.
d. has spread.
ANS: B
Bronchial carcinoma is a malignant cancer of the epithelial lining of the bronchi. Carcinoma refers to a malignant tumor. Primary
indicates that the cancer began in the lungs and did not metastasize from another site. A staging procedure must be done before
knowing if the lung cancer has spread.
REF: Pgs. 114-116
5. Your patient is scheduled for a staging procedure. She wants to know what that means. The correct response is which of the
following?
a. It is a procedure for determining the extent of tumor spread.
b. It is a histologic examination of tissues to determine the degree of tumor
differentiation.
c. Is based on exploratory surgery.
d. It is biochemical testing of tumor cells to determine the genetic basis of the tumor.
ANS: A
Staging describes the location and pattern of spread of a tumor. Staging does not involve biochemical testing of tumor cells, or the
histologic examination of tissues, which is done with cancer grading. CT, MRI, and PET imaging techniques have allowed for
noninvasive cancer detection.